Zac Varghese Selected Research

Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)

10/2014	Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation.
2/2014	Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.
9/2007	Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells.

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Zac Varghese Research Topics

Disease

21	Inflammation (Inflammations) 01/2020 - 01/2003
7	Non-alcoholic Fatty Liver Disease 05/2015 - 09/2008
6	Atherosclerosis 01/2021 - 10/2002
5	Hepatoblastoma 04/2014 - 09/2008
4	Neoplasms (Cancer) 10/2022 - 12/2005
4	Chronic Renal Insufficiency 01/2021 - 12/2009
4	Fibrosis (Cirrhosis) 12/2017 - 10/2011
4	Insulin Resistance 10/2015 - 06/2011
4	Hyperlipidemias (Hyperlipidemia) 05/2015 - 07/2005
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 02/2014
3	Obesity 03/2019 - 12/2005
3	Fatty Liver 01/2019 - 04/2012
2	Neoplasm Metastasis (Metastasis) 10/2022 - 12/2018
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2019 - 12/2018
2	Hyperglycemia 10/2015 - 12/2013
2	Vascular System Injuries 12/2009 - 08/2008
2	Chronic Kidney Failure (Chronic Renal Failure) 08/2008 - 10/2002
1	Hypercholesterolemia 03/2022
1	Hepatocellular Carcinoma (Hepatoma) 03/2022
1	Hyperphosphatemia 01/2021
1	Uremia 01/2021
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Carcinogenesis 12/2018
1	Alcoholic Fatty Liver 01/2018
1	Platelet Glycoprotein IV Deficiency 01/2017
1	Glucose Intolerance 10/2015
1	Necrosis 01/2014
1	Weight Gain 12/2013
1	Infections 04/2012
1	Hyperinsulinism (Hyperinsulinemia) 04/2012
1	Hypertriglyceridemia 04/2012
1	Kidney Diseases (Kidney Disease) 10/2011
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2011
1	Proteinuria 12/2009
1	Dyslipidemias (Dyslipidemia) 10/2007
1	Hypertension (High Blood Pressure) 12/2005
1	Metabolic Diseases (Metabolic Disease) 12/2005
1	Infertility (Sterility) 12/2005
1	Hypertrophy 12/2005

Drug/Important Bio-Agent (IBA)

19	LipidsIBA 10/2022 - 01/2003
13	CholesterolIBA 03/2022 - 07/2005
10	Caseins (Casein)FDA Link 01/2016 - 09/2008
8	Fatty Acids (Saturated Fatty Acids)IBA 10/2022 - 01/2014
5	Sirolimus (Rapamycin)FDA Link 10/2015 - 07/2005
3	Scavenger Receptors (Scavenger Receptor)IBA 10/2022 - 10/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2016
3	CytokinesIBA 05/2015 - 04/2012
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2014 - 09/2007
3	Interleukin-6 (Interleukin 6)IBA 01/2014 - 05/2011
3	ApolipoproteinsIBA 10/2011 - 07/2005
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 09/2008
2	Olive OilIBA 03/2019 - 12/2018
2	Apolipoproteins E (ApoE)IBA 01/2019 - 10/2011
2	Nonesterified Fatty Acids (NEFA)IBA 01/2018 - 06/2011
2	Advanced Glycation End ProductsIBA 12/2017 - 07/2011
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 05/2015
2	Insulin (Novolin)FDA Link 10/2015 - 12/2013
2	TOR Serine-Threonine KinasesIBA 10/2015 - 04/2014
2	LDL Receptors (LDL Receptor)IBA 01/2015 - 10/2011
2	Liver X ReceptorsIBA 01/2015 - 09/2008
2	oxidized low density lipoproteinIBA 01/2013 - 05/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 09/2008
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2012 - 03/2003
1	Sorafenib (BAY 43-9006)FDA Link 03/2022
1	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	MannosidasesIBA 01/2021
1	Purinergic P2X7 ReceptorsIBA 01/2020
1	Dietary Fats (Dietary Fat)IBA 03/2019
1	src-Family KinasesIBA 12/2018
1	Oleic Acid (Oleate)IBA 12/2018
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2018
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2017
1	Phospholipids (Phosphatides)FDA LinkGeneric 12/2017
1	ThrombospondinsIBA 12/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	Malondialdehyde (Propanedial)IBA 01/2016
1	Atorvastatin (Lipitor)FDA Link 01/2016
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2015
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 01/2015
1	Oxidoreductases (Dehydrogenase)IBA 01/2015
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2015
1	PalmitatesIBA 04/2014
1	Blood Glucose (Blood Sugar)IBA 12/2013
1	Bile Acids and Salts (Bile Acids)IBA 05/2012
1	Proteins (Proteins, Gene)FDA Link 05/2012
1	Serine (L-Serine)FDA Link 04/2012
1	Lipase (Acid Lipase)FDA Link 06/2011
1	Sterol Esterase (Hormone-Sensitive Lipase)IBA 06/2011
1	ATP Binding Cassette Transporter 1IBA 12/2009
1	Lipoprotein Receptors (Lipoprotein Receptor)IBA 12/2009
1	PPAR alphaIBA 09/2008
1	Interleukin-1beta (Interleukin 1 beta)IBA 09/2008
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2007
1	Glucose (Dextrose)FDA LinkGeneric 12/2005

Therapy/Procedure

1	Immunotherapy 10/2022
1	Transplantation 10/2007